Tag Archives: serotonin

Anorexia Patients’ Serotonin Levels Helped by Amino Acid Tryptophan

Serotonin is the feel-good chemical that the human brain produces in the body. People with higher serotonin levels generally are more resistant to depression, anxiety, and other negative emotions. People with adequate levels of serotonin also feel better about life, themselves, and their place in the world. Anorexic patients, suffering from the eating disorder called Anorexia nervosa, have mental and emotional as well as physical issues surrounding this disorder, and consequently can have too-low serotonin levels. Raising serotonin can be done by natural means, such as taking the amino acid L-tryptophan. Tryptophan is a neurotransmitter in the brain, which can help raise serotonin levels.

 Tryptophan is used by the body and produces serotonin in the brain, which is severely lacking in those with anorexia. This eating disorder is associated with an obsession of being overweight, so they eat very little, and sometimes nothing at all, which leads to emaciation. Body image issues are at the forefront, self-worth is low, causing a spiraling effect since anorexics think they are too fat even if they are skin and bones. Very low food intake (and therefore low in tryptophan) depletes the serotonin in the brain, since it is tryptophan dependent.

Tryptophan is an amino acid that comes from protein foods, like meats (chicken, beef, pork, lamb, etc.), as well as fish and eggs. A diet deficient in meats is also deficient in not just tryptophan, but also the rest of the common 22 amino acids that make a body healthy and resistant to disease and other health issues.

Study using tryptophan for serotonin levels in anorexic patients

A study by DJ Haleem from the Neuroscience Research Laboratory at the University of Karachi in Pakistan was done regarding anorexia patients and tryptophan. Haleem said “Patients with anorexia nervosa (AN) show extreme dieting weight loss, hyperactivity, depression/anxiety, self-control, and behavioral impulsivity. Tryptophan, the precursor of serotonin and an essential amino acid, is only available in the diet. It is therefore likely that excessive diet restriction and malnutrition decrease brain serotonin stores.”

When serotonin is low, then the availability of tryptophan “decreases serotonin neurotransmission at postsynaptic sites, leading to hyperactivity, depression, and behavioral impulsivity,” said Haleem. He suggested that tryptophan “supplementation may improve pharmacotherapy in AN.”

The effectiveness of tryptophan on serotonin levels for anorexia has not yet been evaluated, but the fact that higher serotonin levels make us feel better is well documented. Tryptophan is an amino acid that is easily bought over the counter at health food stores for supplementing the diet.

References:

http://www.ncbi.nlm.nih.gov/pubmed/22854305

http://www.mayoclinic.com/health/anorexia/DS00606

Nutrition and Depression: Amino Acids Can Improve Mood

We all know the importance of eating well. The link between an unhealthy diet and obesity, heart disease, and diabetes has led to bookshelves groaning with diet and nutrition books. But nutrition also affects our mental wellbeing. Are we getting enough amino acids to maintain our mental health?

A good diet is our best weapon in the war on disease. A healthy, well-balanced diet will also help our immune systems if we do become ill. This healthy diet will help combat some mental illnesses, too.

T. S. Sathyanarayana Rao, M. R. Asha, et al, explained the link between nutrition and depression in an article in the Indian Journal of Psychiatry. They found that the diets of many people suffering from mental disorders are deficient in essential vitamins, minerals, and omega-3 fatty acids.

Supplements containing amino acids have been found to reduce symptoms of depression. Some amino acids control our moods—they cross the blood-brain barrier, carrying the chemical signals in our brains. But if we are not getting the right amount, our moods are affected.

Amino acid supplements treat mood disorders

The major symptoms of depression include increased sadness and anxiety, loss of appetite, and loss of interest in pleasurable activities. Deficiencies in neurotransmitters like serotonin, dopamine, noradrenaline, and the amino acid GABA are often present patients with depression.

The amino acids tryptophan, tyrosine, phenylalanine, and methionine are often helpful in treating mood disorders. Indeed, tryptophan is converted to serotonin–the chemical which controls happiness.

Tryptophan is an essential amino acid, which means we must get it from our food. But people with poor diets do not get enough tryptophan.

Antidepressants and other drugs are very successful at treating depression. The researchers hope that nutritional supplements containing amino acids will work with these drugs, possibly leading to lower doses, and fewer side effects. They suggest daily supplements of amino acids to help achieve an antidepressant effect.

Nutritional neuroscience gives us our best shot of preventing and treating some mental illnesses.

Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738337/