Tag Archives: prostate cancer

Prevent Prostate Cancer with Three Amino Acids?

Three specific amino acids may aid in the prevention of prostate cancer according to a study. The three aminos include methionine, phenylalanine, and tyrosine. During protein synthesis by the body, the amino acids tyrosine, methionine, and phenylalanine are utilized. Restriction of these amino acids depends on glucose metabolism, which when altered aids in cell death of cancer cells within human prostate cancer, and may aid in preventing prostate cancer.

Study linking amino acids and prostate cancer prevention

YM Fu, H Lin, et al., did a study at the Department of Pharmaceutical Sciences at Washington State University said that it is selective amino acid restriction of tyrosine and phenylalanine, plus methionine or glutamine that target mitochondria in cells that are linked to prostate cancer cell death.

Glucose metabolism modulation is tied to the process and “crucial switches connecting metabolism and these signaling molecules to cell survival during amino acid restriction” become target factors preventing prostate cancer, say the researchers.

Second study on prostate cancer and amino acids

Another study by YS Kim from Washington State University showed an identification of molecular targets regarding specific amino acid dependency and how it modulates specific kinds of prostate cancer cells. To find out how the amino acids can prevent prostate cancer, they investigated if restriction of tyrosine, phenylalanine, and methionine could inhibit the growth and metastasis of prostate cancer.

Kim progressed outward in this field of research because of the “underlying the anticancer activity of tyrosine/phenylalanine and methionine restriction. This is especially important research since there still is no satisfactory drug for treatment of androgen-independent, metastatic human prostate cancer.”

Even though further research is needed regarding the amino acids phenylalanine, tyrosine, and methionine for prostate cancer prevention, it has expanded avenues for antimetastatic, anti-invasive, apoptosis-based therapies for the preventing prostate cancer.

Prostate cancer, being one of the major cancers that kill men in the North American continent, is the reason why males should be regularly screened for this deadly disease.

Reference:

http://www.ncbi.nlm.nih.gov/pubmed/20432447

http://prevention.cancer.gov/funding/recently-funded/ca04004/1R01CA101035-01A1

Amino Acids Lysine, Proline, Arginine To Treat Prostate Cancer

A study into the anti-tumor effects of specific nutrients has led to positive results. A unique amino acids-plus formulation of lysine, proline, arginine, ascorbic acid, and epigallocatechin gallate was proved to have anticancer properties, and could become a natural anticancer agent to treat prostate cancer. 

Prostate cancer is the most common cancer among men, after skin cancer. In fact, about 1 man in 6 will be diagnosed with prostate cancer (U.S. data). But prostate cancer can often be treated successfully, especially if detected early.

Prostate cancer can often be found by testing for a prostate-specific antigen in the blood. A digital rectal exam is also a common screening technique. Once diagnosed and staged, prostate cancer can be treated with surgery, radiation therapy, cryotherapy, chemotherapy, hormone therapy, and other treatments.

Because some treatments, like chemotherapy, have severe side effects, scientists worldwide are studying new, non-toxic anti-cancer therapies, including some amino acids.

Amino acids nutrient study results: proliferation of prostate cancer cells reduced

Researchers Roomi MW, Ivanov V, et al, from the Matthias Rath Research, Cancer Division, Santa Clara, USA, developed a unique formula containing specific amino acids to treat prostate cancer cell lines.

Various concentrations of the amino acids lysine, proline, and arginine, were combined with ascorbic acid and epigallocatechin gallate. This mixture was tested on prostate cancer cell lines in vitro. The proliferation, or growth, of prostate cancer cells was measured.

Lysine is one of the essential amino acids, which means we must ingest it since our bodies cannot produce it by themselves. The two amino acids proline and arginine are synthesized in our bodies, though of course all amino acids can be consumed as supplements or can come from eating certain protein foods, including meats.

Results of the study were impressive. The amino acids-plus mixture produced a dose-dependent inhibition of some of the prostate cancer cell lines. The researchers concluded that the lysine, proline, and arginine amino acids, ascorbic acid, and epigallocatechin gallate mixture could become a potent anticancer agent, and could be a new treatment for prostate cancer.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/17564322