Tag Archives: prevent cancer

Prevent Prostate Cancer with Three Amino Acids?

Three specific amino acids may aid in the prevention of prostate cancer according to a study. The three aminos include methionine, phenylalanine, and tyrosine. During protein synthesis by the body, the amino acids tyrosine, methionine, and phenylalanine are utilized. Restriction of these amino acids depends on glucose metabolism, which when altered aids in cell death of cancer cells within human prostate cancer, and may aid in preventing prostate cancer.

Study linking amino acids and prostate cancer prevention

YM Fu, H Lin, et al., did a study at the Department of Pharmaceutical Sciences at Washington State University said that it is selective amino acid restriction of tyrosine and phenylalanine, plus methionine or glutamine that target mitochondria in cells that are linked to prostate cancer cell death.

Glucose metabolism modulation is tied to the process and “crucial switches connecting metabolism and these signaling molecules to cell survival during amino acid restriction” become target factors preventing prostate cancer, say the researchers.

Second study on prostate cancer and amino acids

Another study by YS Kim from Washington State University showed an identification of molecular targets regarding specific amino acid dependency and how it modulates specific kinds of prostate cancer cells. To find out how the amino acids can prevent prostate cancer, they investigated if restriction of tyrosine, phenylalanine, and methionine could inhibit the growth and metastasis of prostate cancer.

Kim progressed outward in this field of research because of the “underlying the anticancer activity of tyrosine/phenylalanine and methionine restriction. This is especially important research since there still is no satisfactory drug for treatment of androgen-independent, metastatic human prostate cancer.”

Even though further research is needed regarding the amino acids phenylalanine, tyrosine, and methionine for prostate cancer prevention, it has expanded avenues for antimetastatic, anti-invasive, apoptosis-based therapies for the preventing prostate cancer.

Prostate cancer, being one of the major cancers that kill men in the North American continent, is the reason why males should be regularly screened for this deadly disease.

Reference:

http://www.ncbi.nlm.nih.gov/pubmed/20432447

http://prevention.cancer.gov/funding/recently-funded/ca04004/1R01CA101035-01A1

Arginine Slows Proliferation And Growth Of Lung Cancer Cells

Some promising news about the treatment of lung cancer was published in the American Journal of Cancer Research. The essential amino acid arginine is being developed into an effective anti-cancer agent. Synthesized arginine/albumin microspheres have been designed to combat lung cancer.

Lung cancer is one of the leading causes of cancer-related death. As with all cancers, early detection is the best hope for successful treatment. However, the early stages of lung cancer usually do not produce symptoms. As the cancer advances, symptoms develop, including coughing, wheezing, and coughing up bloody mucus.

Treatment can include surgery, chemotherapy, and radiation. Recent clinical trials have focused on endobronchial intratumoral chemotherapy, which is the direct injection of the drug into the tumor.

Arginine, an essential amino acid, also known as L-arginine, is already proved to inhibit cancer cell proliferation in various cancers, including lung, breast, and gastric cancer cell lines when an appropriate dose is delivered. High concentrations of arginine incudes cancer cell death. Arginine also assembles into clusters to kill cancer cells.

Researchers (HY Lee, KA Mohammed, et al) from the University of Florida, USA, developed a study to investigate the delivery method of L-arginine in endobronchial intratumoral chemotherapy. They designed arginine/albumin microspheres to deliver high concentrations of arginine to the tumors.

Microspheres of synthesized arginine prevent lung cancer cells proliferating

The researchers tested arginine/albumin microspheres on A549, a human lung carcinoma cell line. And arginine/albumin mesospheres (AAMS) were synthesized which promotes arginine clusters. These AAMS consisted of 50% arginine and 50% bovine serum albumin. The minute microspheres were solidified in a centrifuge tube.

This in vitro study produced very positive results. The arginine significantly inhibited cell proliferation, cell migration, and tumor growth of the lung cancer cells. The synthesized AAMS were more effective than freely released arginine, indicating that AAMS could become an ideal delivery vehicle for lung cancer treatments.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/23841026

L-arginine Prevents Gastric Cancer Cell Growth

More interesting news about the anti-cancer effects of the essential amino acid L-arginine (or simply, arginine). A European study investigated the effects of L-arginine on tumor cell growth on human gastric cancer cell lines. Would L-arginine promote cancer cell death?

Gastric, or stomach, cancers have a poor prognosis because they develop slowly over many years without producing symptoms. By the time symptoms occur, the cancer may have spread, or metastasized, which is much more difficult to treat. The 5-year survival rate is only 5-15%.

Most stomach cancers are adenocarcinomas, which develop from the cells lining the stomach.  Smoking irritates these cells, and smoking greatly increases the risk of developing gastric cancer. Eating a diet high in antioxidant-rich foods, such as fresh berries, could reduce the risk.

S Nanthakumaran, I Brown, et al, researchers at the University of Aberdeen’s College of Life Sciences and Medicine, in Scotland, UK, developed a study on immunonutrition. Immunonutrition is the development of nutritional components that favorably affect the immune function.

The researchers wanted to examine the effects of the amino acid L-arginine on tumor cell growth, cancer cell invasion, and the cancer’s effect on gene expression.

Can L-arginine help treat stomach cancer?

L-arginine is already proven to enhance the immune system, and reduce infectious complications in patients undergoing gastrointestinal surgery.  Healthy people are usually able to synthesize enough L-arginine in their bodies. However, L-arginine supplements are useful for people with surgical or other traumas.

In order study L-arginine’s effect on tumor cells, the researchers grew human gastric cancer cell lines in vitro. Different concentrations of L-arginine were tested.

L-arginine caused the cancer cells to die, by inducing cancer cell apoptosis  (programmed cell death).The researchers discovered cell growth inhibition was caused by the L-arginine increasing the expression of a significant protein: caspase 8. Caspases play an essential role in promoting apoptosis.

L-arginine, therefore, has the potential of being developed into an anti-cancer agent.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/19036482/