Tag Archives: pain relief

Phenylalanine for Pain Relief and Other Health Benefits

Phenylalanine is an essential amino acid, in which “essential” means you must get it through your diet or supplementation since your body cannot produce it on its own. Phenylalanine also is known as nature’s pain reliever. 

Interestingly, Phenylalanine is used in psychotropic drugs such as morphine, codeine, papaverine, and even mescaline because it is such an effective pain reliever.

Phenylalanine: How is it used in the body as a pain reliever?

Phenylalanine is one of the three aromatic amino acids, which include the other two, Tyrosine and Tryptophan. Phenylalanine is also the precursor for Tyrosine, and like Tyrosine, Phenylalanine is the precursor in the human body of catecholamines, which include dopamine, epinephrine, norepinephrine, and tryamine.

Dr. Winston Greene at DC Nutrition explains what catecholamines are and why we need phenylalanine, and how much: “Phenylalanine is a precursor of the neurotransmitters called catecholamines, which are adrenalin-like substances. … is highly concentrated in the human brain and plasma. … and requires biopterin, iron, niacin, vitamin B6, copper and vitamin C. An average adult ingests 5 g of phenylalanine per day and may optimally need up to 8 g daily.”

Phenylalanine essential amino acid comes from food and levels affect pain relief

You can get Phenylalanine from protein foods such as beef, chicken, fish, eggs, dairy products, and wheat germ. Dr. Greene shows that not only is this amino acid good as a pain reliever, but also that it is low in people who ingest caffeine. Interestingly, depressed people often seek out stimulants like caffeine drinks as a “pick me up” but may be doing themselves further harm since Dr. Greene says they’d found that “about 10 percent of depressed patients have low plasma Phenylalanine, and phenylalanine is an effective treatment in these cases.”

When someone gets an infection, however, Phenylalanine levels increase in the body to help aid any pain that might be associated with it, again acting as nature’s pain reliever. This amino is used in “premenstrual syndrome and Parkinson’s may enhance the effects of acupuncture and electric transcutaneous nerve stimulation (TENS). Phenylalanine and tyrosine, like L-dopa, produce a catecholamine effect. Phenylalanine is better absorbed than tyrosine and may cause fewer headaches.”

The bottom line is that Phenylalanine can be a great natural source for pain relief for numerous problems from infection to PMS to diseases such as Parkinsons. The health benefits are numerous, but always be sure to check with your doctor prior to any supplementation or changes to your diet when working to include this amazing amino acid for pain relief.

Reference:

http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aromatic.html

http://www.dcnutrition.com/AminoAcids/Detail.CFM?

Amino Acids as Anti-Inflammatory Pain Relief

Did you know that amino acids can be used for pain relief? People often will take over the counter painkillers like acetomenaphen (e.g., Tylenol), or anti-inflammatories like ibuprofen (e.g., Advil), but a natural source of analgesics with some anti-inflammatory effects include amino acids. Amino acids are known as the building blocks of proteins, but they serve many functions in the body, especially to the organs and brain, or even the muscles and nerves. Taking amino acid supplements can sometimes aid the body to ward off pain and inflammation, just like a natural painkiller.

There are a couple of studies that tested amino acids like L-isoleucine, which can act as an agent for pain relief, and so prostaglandin was studied to see the effectiveness of L-isoleucine for the analgesic (painkilling) and anti-inflammatory properties. In order to understand how this works we must understand how prostaglandin works…

Prostaglandins are lipid compounds that work on-site like Aspirin; however, they are enzymatically derived (from fatty acids). Although prostaglandins work in a variety of ways, one of them is by acting as an analgesic, or natural pain reliever. Analgesics help your body achieve analgesia—relief from pain.

When there is an injury or you are will, the prostaglandins (whether due to amino acids or medicine) do not get secreted from the gland, but instead are chemically made on-site so they can be used exactly where they are needed, such as to control or reduce inflammation.

Amino acids studied as analgesics (pain relievers)

One study by E Ricciotti and GA FitzGerald regarding prostaglandins showed that they can act as a natural painkiller and help reduce the anti-inflammatory response. The researchers said, “prostaglandins may function in both the promotion and resolution of inflammation.” But amino acids may also cause a bodily anti-inflammatory response.

In a different study, four amino acids were investigated. The scientists RN Saxena, VK Pendse, and NK Khanna “Orally administered L-isoleucine, DL-isoleucine and L-leucine [which] exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only.”

Interestingly, it was the L-isoleucine that showed an extended analgesic (painkiller) result. Meanwhile, DL-isoleucine did have a short-lasting effect.

Unlike some supplements, the amino acids did not cause gastric ulceration nor did it promote acute toxicity in the doses that suppressed inflammation effectively. The researchers’ assessment on the painkilling amino acids included that the “anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.”

Of course, it depends on the problem and which amino acids you can use to act as a natural painkiller against it, so more research will continue in this area as time progresses.

References:

http://www.ncbi.nlm.nih.gov/pubmed/6335992

http://www.ncbi.nlm.nih.gov/pubmed/21508345