Tag Archives: natural sedative

GABA Stops or Prevents Seizures

GABA, also referred to a gamma-aminobutyric acid, is an amino acid. Amino acids are the building blocks of proteins and serve different functions in the body. Historically this amino has been used as a natural sedative, to help with relaxation and sleep since it is acts as a neurotransmitter in the brain. However, it also has anti-anxiety and anti-seizure properties, and is an anti-convulsant.

GABA is a non-essential amino acid, meaning that the body produces it (you can also get it from protein foods or take a supplement) but sometimes it is still deficient depending on what is happening in the body.

According to studies, this amino acid can aid with sleep, inhibition, calming the nerves, drug dependency (including alcoholism), is used in antiepileptic drugs (epilepsy), and according to a study entitled ‘Molecular mechanisms of antiseizure drug activity at GABAA receptors’ by L John Greenfield Jr, is used to prevent seizures.

GABAA receptor (GABAR) helps prevent seizures

GABAA receptor (GABAAR) is, says the researcher, a “major target of antiseizure drugs (ASD’s).” There are actually a number of different agents that act at GABARs’ distinct receptor sites that can eliminate or prevent seizures.

Some of these agents include: loreclezole, benzodiazepines, and barbiturates, in which the GABARs are the only known substance used due to its antiseizure ability.

However, this is only one of a few possible antiseizure mechanisms in these agents: topiramate, losigamone, retigabine, felbamate, and stiripentol.

Other agents, which affect GABAergic “’tone’ by regulating the synthesis, transport or breakdown of GABA” also exist. The development of ganaxolone was a response to the neurosteroid allopregnanolone (a progesterone metabolite, which intensifies GABAR function).

This amino is an intrinsic component to epileptic patients. The efficacy of GABAR function can change when someone develops or has chronic epilepsy, so Greenfield says that it “may provide an additional target for ‘GABAergic; ASDs.”

The conclusion was that targeting the altered receptors may “provide a novel approach for seizure prevention.”



What Can GABA Amino Acid Do For Me?

GABA amino acid supplements can help you with a number of things. This is a chemical that exists in all of us and plays an important role in how we live our lives.  Here is a little information on it so you can see whether or not it’s a good idea to use it as a supplement.

GABA is something that’s created in your body naturally and it is required to keep your mood in check.  It helps control the fight or flight response and this means that in a lot of people, it controls how much anxiety they feel. People that don’t have the correct balance of GABA amino acid chemicals in their brains are going to feel a lot of anxiety and may have a lot of manic behavior problems. This is why it’s important to take these kinds of supplements if you have any problems with these issues. If you’ve ever drank alcohol then you know that it lowers your inhibitions. This is because it acts on the part of the brain that is responsible for GABA production. When this balance is thrown off, then you’re more likely to do things that you wouldn’t normally do. When the alcohol wears off and you feel all of those anxious feelings, that is because your GABA balance is off. You can only make things better if you abstain from alcohol and use this kind of supplement for it to be effective. Speak with a doctor if you struggle with addiction. You should now know a little more about GABA amino acid and how it can help you if you need it. Make sure that if you do have any extra questions, you ask them to your doctor just so that you can be safe.

Read more comprehensive reports and scientific studies on GABA in the GABA section of our site.

This document was produced by a third party article provider. The opinions and statements are of that organization’s own and the owner and publisher of the site assume no responsibility for the accuracy of the content. Our articles are for informational, educational and entertainment purposes only. Please do your own due diligence, verify any health claims by doing additional research and consult your doctor before starting any supplementation program or making any lifestyle changes, including changes to your medication and supplementation.

Kill the Pain with Amino Acid GABA – Gamma-aminobutyric acid: Nature’s Pain Killer

Health Benefits of amino acid GABA: Pain Relief, Sleep, and Reduced Anxiety

GABA—known as Gamma-amnobutyric acid—is a chief neurotransmitter with inhibitory effects on the central nervous system of mammals. Because it plays a central role in regulating the excitement of neurons in the brain and nervous sytem, as well as muscle tone in humans, it can be used as a pain killer as since it not only reduces the perception of pain, but also has secondary effects that allows sleep and reduces anxiety once the pain is gone.

GABA is an amino acid, chemically speaking, but in medical and scientific fields it is referred to differently since it is not an alpha amino acid and is not technically incorporated into a protein either. However, Gaba-A and Gaba-B receptor sites in the brain do have a role to play in pain regulation, sleep, and anxiety parts of the human body and psyche.

Perception and mediation of pain: Pain killers as regulated by GABA amino acid

Defining the role of GABA regarding the perception and mediation of the transmission of pain has been attempted by SJ Enna and KE McCarson in the Department of Molecular and Integrative Physiology, at the University of Kansas Medical Center. They understand why GABA is nature’s pain killer.

Realizing that the central nervous system has GABAergic neurons that are distributed throughout the body, it is the spinal cord dorsal horn that also transmits the impulses of what it perceives as “pain” to the brain. GABA neurons and receptors not only perceive and respond to the stimuli, but these scientists admit that “this neurotransmitter system has been shown to regulate control of sensory information processing in the spinal cord.” This is why GABA plays such an important role in being a natural pain killer and is considered a novel analgesic.

One limitation to GABAergic drugs in the past has been the problem of sedation, or the induction of sleep, which is fine for patients who need to both receive sleep as well as pain relief from this natural pain killer source. However, because it helps with sleep, and not all patients want to sleep but just have the effects of a pain killer, it has shown to be of limited utility. Research continues with GABA-A and GABA-B receptor sites, with the latter being identified with antinociceptive (pain killer) responses “at doses well below those that cause sedation.”

This research has shown hope towards GABA as a pain killer regulator since “stimulation of neuroanatomically discreet GABA receptor sites could be of benefit in the management of pain.” It is good to know that continued research is being done in this area of natural pain killers via GABAergic drugs.