Tag Archives: memory

Phenylalanine Hydroxylase and Memory Performance

Phenylalanine, an essential amino acid, is the precursor to amino acid tyrosine, which helps regulate dopamine, noradrenaline and adrenaline. Found naturally in breast milk, phenylalanine is said to have analgesic and antidepressant qualities. Phenylalanine hydroxylase (PAH) is the enzyme that catalyzes phenylalanine to tyrosine. Mutations in PAH can cause phenylketonuria (PKU), the inability to metabolize phenylalanine and a genetic disorder that can lead to intellectual disability, seizures, motor disorder and skin rashes when not monitored. Because of this association of genetic variations to cognitive ability, researchers at the National Center of Neurology and Psychiatry in Japan set out to test the effect of variations, or single nucleotide polymorphisms, of PAH on memory performance in humans.

For the experiment, researchers Toshiya Teraishi et al. used 599 healthy participants. All participants underwent interviews to make sure they had no history with psychological disorders. They were then given the Wechsler Memory Scale-Revised to evaluate memory performance in five parts: verbal memory, visual memory, general memory, attention and delayed recall. Blood samples were also taken to determine the genomic DNA of the participants and tag six different single nucleotide polymorphisms (SNP) of PAH.

The effect of variations of PAH on memory

After analyzing the test scores and associated SNPs of phenylalanine hydroxylase of the participants, researchers Teraishi et al. found a significant association of the verbal memory set of the score with five SNPs. This suggests that common variations in PAH, specifically variations with SNP marker rs2037639 and haplotype markers rs2037639 and rs10860936, can have an effect on verbal memory performance.

Because SNP rs2037639 was found in previous studies to be associated with schizophrenia in sample of Bulgarian men, the researchers believe that the particular SNP variation increases an individual’s susceptibility to the mental disorder by affecting memory performance.

They report that verbal memory is one of the most altered neurocognitive function for schizophrenics.

Source:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733818/

Antiaging Treatments – GABA Amino Acid, Lifestyle, or Ikaria?

Antiaging treatments have included creams and lotions, or even food and potions. People and even experts say things like… drink this, eat that, live here, go there, exercise more, eat less, eat healthier, live in the Andes mountains, take this supplement (like GABA amino acid), take that supplement (like Reishi medicinal mushrooms). 

Antiaging may even include a move to Ikaria (known as Icaria, a Greek island) like Stamatis Moraitis did, according to the New York Times article entitled: The Island Where People Forget to Die, discussing how he overcame cancer merely by choosing to move back home and altering his lifestyle. Stamatis Moraitis is a centenarian, meaning he is over one hundred years old, and still alive and well, sharp as a tack, and happy and healthy.

Anti-aging techniques and treatments for some people may or may not include GABA amino acid supplements, or a lot of small changes in lifestyle (or major ones, depending), but one thing is for sure… it is not usually just one thing, but a combination of many. Longevity can include heredity/genetics as well as environmental factors.

Longevity and aging gracefully may include supplements like GABA amino acid

Aging is associated with the body’s cells breaking down over time and not functioning at the levels that they used to when people were younger. Cells die and are not regenerated the same way. To overcome physical or biological entropy it is often recommended that not just living somewhere or eating a certain way is key (although both can promote health benefits, depending on the person), but sometimes changing all the “little things” in life so that they add up to become the “big things” all by themselves.

Little things can include dietary changes, exercise regimens, breathing techniques and yoga, distressing, skipping fast food and eating fresh fruit instead, and even taking GABA amino acid supplements.

What can GABA amino acid supplements do for you?

According to a demographic study by SV Ukraintseva, KG Arbeev, et al., on antiaging treatments, many of them legally prescribed for thirty years, more or less, some of the “most common of the relevant medicines are nootropic piracetam, gamma-aminobutyric acid (GABA), selegiline, Ginkgo biloba, pentoxifylline, cerebrolysin, solcoseryl, ergoloid, vinpocetin, sertraline, and estrogens, among others.” GABA amino acid is one of these popular items used for supplementation and antiaging.

GABA amino acid can have a variety of effects on your body, mind, and health. A general overview is covered in the article What Can GABA Amino Acid Do For Me?

GABA amino acid is also used to feel better, especially when one is in pain. Kill the Pain with Amino Acid GABA – Gamma-aminobutyric acid: Nature’s Pain Killer is an article on this very topic. Isn’t part of growing old feeling good and not being subject constantly to joints and inflammation, aches, and pains?

Additionally, protecting your brain and stimulating your senses and memory are key factors. Learning a language, or even knowing what GABA amino acid supplements can do to help your brain and memory or cognition can be read about here in Amino Acid GABA Vital For Normal Brain Activity And Memory. Memory is often a problem with dementia and Alzheimer’s as one gets older.

Although GABA amino acid is not the cure-all for all ailments, it is one of the many “little things” one can do to reduce pain, combat aging and restore a sense of youthfulness, health and wellness, and memory abilities. Perhaps it could still be included in many peoples’ little box of secret weapons against aging.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/15246996

http://www.nytimes.com/2012/10/28/magazine/the-island-where-people-forget-to-die.html?smid=fb-share&_r=0