Tag Archives: L-glutamine

Glutamine Deprivation May Slow Pancreatic Cancer

Tumor growth in pancreatic cancer patients may be slowed using glutamine. Glutamine is an amino acid, which is one of the building blocks of proteins. Although it is typically considered a non-essential amino acid (meaning the body may make it on its own), glutamine is technically a conditionally essential amino acid. The term “essential” means that it must be gotten through the diet, so this amino acid is—in certain circumstances—acquired via intake of food.

Glutamine, which is the most abundant amino acid in the human body, plays a role in cancer tumor growth; so depriving the cancer cells of glutamine may hold the key to slowing the spread of cancer of the pancreas, a study shows.

Study on pancreatic tumor growth and glutamine

At the Division of Genomic Stability and DNA Repair, Department of Radiation Oncology (part of the Dana-Farber Cancer Institute) in Boston, Massachusetts, a group of researchers and doctors, J Son, CA Lyssiotis, et al., have investigated just how the amino acid glutamine is involved with the KRAS-regulated metabolic pathway, which is part of the cause of tumor growth within the pancreas itself.

The researchers studied the metabolism of cancer cells and glutamine dependencies since, unlike normal cells, the cells within cancer tumors maintain their own type of metabolism. They said that “an increased use of the amino acid glutamine to fuel anabolic processes. Indeed, the spectrum of glutamine-dependent tumors and the mechanisms whereby glutamine supports cancer metabolism remain areas of active investigation.”

Because human pancreatic cells use a non-standard pathway, which identifies ductal adenocarcinoma (PDAC) cells, most cells use “glutamate dehydrogenase (GLUD1) to convert glutamine-derived glutamate.” What this means is that the PDAC cells “are strongly dependent … as glutamine deprivation or genetic inhibition of any enzyme in this pathway leads to [a] series of reactions [that] results in a pronounced suppression of PDAC growth in vitro and in vivo.”

The scientists established that because the glutamine metabolism is reprogrammed and “mediated by oncogenic KRAS, the signature genetic alteration in PDAC [represses] key metabolic enzymes in this pathway.”

With the PDAC pathway and pancreatic cells being dispensable, the glutamine in normal cells then becomes a possible new therapeutic approach in treating pancreatic tumors in humans. Hopefully more will be forthcoming on this new technique in the near future.



Heart Bypass Surgery and L-glutamine Perioperative Care

A study investigated the protective effects of L-glutamine in coronary bypass surgery, with positive results. 

Ischemic heart disease, often known also as myocardial ischemia, is characterized by reduced blood supply to the heart muscle. The heart becomes weaker, unable to pump blood effectively round the body. This is usually caused by coronary artery disease, or atherosclerosis, which is hardening of the arteries.

Ischemic heart disease is the most common cause of death worldwide. However, it can often be prevented. Risk factors include obesity, smoking, high cholesterol, and high blood pressure, which can all be addressed with lifestyle changes.

However, the risks of developing heart disease also depend on age, genetic factors, and diabetes.

Coronary artery bypass surgery  is one of the treatments for ischemic heart disease. A Cardiopulmonary bypass  is often a part of this heart surgery. The cardiopulmonary bypass is a technique which temporarily takes over the functioning of the heart, because it’s extremely difficult to operate on a beating heart.

Researchers W Lomivorotov, S Efremov, et al, wanted to see if the amino acid L-glutamine had cardioprotective effects during a cardiopulmonary bypass. They published their findings in the Russian journal Anesteziologiia i Reanimatologiia, or Anesthesiology and Intensive Care.

L-glutamine to be part of perioperative care for heart surgery?

Patients were divided into the study group and the control group. The study group was administered L-glutamine, specifically a 20% solution N(2)-L-alanine-L-glutamine. The control group received a placebo solution.

The solutions were given during the perioperative period, which is the entire surgical procedure including admission, anesthesia, surgery, and recovery. The goal of perioperative care is to provide better conditions for patients before, during, and after their surgery.

In this study, the L-glutamine solution provided an excellent perioperative addition for patients with ischemic heart disease up to 24 hours after surgery. The L-glutamine solution had a significant cardioprotecive effect, and could become a standard part of treatment for these ischemic heart disease patients if they need to have heart surgery.



Glutamine: The Anti-Aging Amino Acid for Your Skin

Anti-aging amino acids like glutamine may help your skin appear more youthful. Aging causes our bodies’ cells to break down or regenerate as they did in our youth. Cells die but do not renew at the same rate for healing or health like when we were young. 

The triggers for aging can include DNA, but many times environment also plays a role. This environmental impact can include diet… anti-aging amino acids like glutamine can include essential and non-essential amino acids.

Essential aminos can be gotten through diet, whereas non-essential aminos are made by our bodies; but as we grow older our bodies do not always produce what we need and may require supplementation. Glutamine is a non-essential amino acid.

Anti-aging amino acids include glutamine for acid-base balancing and firming of skin

Consider glutamine (L-glutamine) for acid-base balancing and firming of the skin. Proper nutrients, such as is found in a raw food diet, while eliminating or vastly reducing disease-causing hyperacidity foods like fast foods, “white foods” (sugar, white flour, white rice and potatoes), coffee, excess meat, or nicotine, is one of the major components to healthy skin and anti-aging all the way around.

Glutamine aids the acid-base balance in the body by moving ammonia out of the kidneys. By ridding acid from the body, and the preservation of bicarbonate, the acid levels are neutralized. Glutamine is a massive supporting factor in this acid-base balance.

We are not able to support anti-aging amino acids like glutamine in the body even though it is a non-essential amino acid, because as we age our ability to produce aminos—just like the ability to regenerate cells—reduces in volume and quality, causing aging effects.

Please discuss the inclusion of the amino acid glutamine in your diet or through supplementation with your doctor or naturopathic physician. Glutamine just might be able to help your skin look younger, while also providing you with an acid-base balancing that is a necessary component of a healthy diet and lifestyle to keep you looking young!



L-glutamine Improves Gastrectomy Surgery Recovery Rate

All surgeries can result in complications, which can sometimes be fatal. A new study investigates the effects of giving L-glutamine supplements to gastrectomy patients… the amino acid may help patients recover faster and go home sooner.

Gastrectomy is a partial, or full, surgical removal of the stomach. The study investigated minimally-invasive partial gastrectomies. Gastrectomies are used to treat cancer, tumors, polyps, inflammation, and bleeding.

Gastrectomy is a minimally invasive surgery, but as with all surgeries, complications can develop. CC Chen, TC Chang, et al, with the Department of Surgery, National Taiwan University Hospital, Taipei, China, developed a trial to reduce the risk of complications.

They gave L-glutamine supplements to the patients after surgery. L-glutamine is an amino acid with many biochemical functions. It’s one of the most abundant nonessential amino acids, which means it’s created in our bodies from other amino acids. However, in cases of illness or injury, it becomes conditionally essential, meaning we must obtain it from food or supplements.

Some people take L-glutamine supplements for digestive issues. L-glutamine’s protective effect in the gastrointestinal tract is the subject of clinical trials, where L-glutamine supplementation has been used successfully to improve inflammatory bowel disease.

L-glutamine supplement after surgery trial: good results

The trial reviewed 155 patients, who had been treated over a period of three years from 2005 to 2008. There were three groups of patients.

Two of these groups had subtotal gastrectomies by laparotomy, but only one group was given the L-glutamine supplement. Laparotomies involve a large incision through the abdominal wall.

The third group had gasless laparoscopy-assisted subtotal gastrectomies. All patients in this group were given the L-glutamine supplement.

Laparoscopies, sometimes known as keyhole surgery, are minimally invasive, consisting of a few small surgical cuts, with the surgeons using a camera for precision.

Both the L-glutamine groups had significant improvements in postoperative heart rates. They also experienced less tenderness, and therefore recovered from the surgery faster.

In addition to improving patient care, faster recovery means that the patients can go home sooner, thus freeing hospital beds for other patients, and saving money.

The researchers concluded with positive news for gastrectomy patients. The L-glutamine supplements speeded recovery times, and reduced the risk of developing complications.



Dr. Oz: L-Glutamine, L-Arginine and Weight Loss

According to Dr. Oz, there are three amino acids that can help with weight loss: L-Carnitine, L-Glutamine, and L-Arginine. But first we must know what weight loss problems we are dealing with… the weight loss amino acids are simply not enough if we did not mention what specific issues they will help.

There are a number of issues that go along with weight gain and obesity. Dr Oz has discussed all of them at one time or another, surely, from lacking energy, weight management, storing food as fat or sugar (glycogen in particular), and sluggish metabolism rates.

All of these can be helped by these three weight loss amino acids, but which goes with which?

Here’s a simple guide…

Amino Acids for Weight Loss

L-Carnitine for Weight Loss

One of the issues with losing weight is maintaining the weight once you’ve lost it. It is common for people to gain the weight back, and slip back into old habits. The amino acid L-carnitine can help you to get a hold on your weight management.

L-carinitine is also known for supplying your body with energy since it releases stored energy. Sometimes when caloric intake is reduced people get weak feeling, or lack the energy to stay awake, or get out and do things (even taking a walk can seem like too great an exertion). L-carnitine can help release the energy you need to move forward in your diet plan.

L-Glutamine for Weight Loss

Many times the food we eat gets stored as fat in the body. L-glutamine can help your body store the energy as a sugar called glycogen instead of fat, which makes it more usable by the body and easier to get rid of later.

Glycogen is stored in the muscles and liver and plays an important role in the body’s glucose cycle. This can be used for quick energy, whereas fat takes longer to utilize and eliminate.

L-Arginine for Weight Loss

Metabolism is a huge indicator in many people on whether they are prone to obesity or not. Having a slow metabolism can be a single inhibitor to weight loss, when everything else seems to be going well for others on a similar diet. L-arginine is considered the natural metabolism booster.

Remember that you can get all three of these amino acids (all 22 aminos, actually) from food, and protein foods in particular. It doesn’t take much protein since all meats like beef, chicken, and pork have all the amino acids, as do fish and eggs.

However, discuss with your doctor about taking the weight loss amino acids L-carnitine (weight management and energy), L-glutamine (storing sugar as glycogen instead of fat), and L-arginine (metabolism booster).



Glutamine Supplement: New Therapy For Ulcerative Colitis?

An animal study from Japan has found good news for ulcerative colitis sufferers. There is a possible new supplement, enriched with L-glutamine amino acid available on the market. This glutamine supplement could improve symptoms of colitis.

Ulcerative colitis is a chronic, long lasting disease. It’s an autoimmune disease, one of the forms of inflammatory bowel disease (IBD).  Crohn’s disease is the other form of IBD.

Ulcerative colitis is a very painful condition which results in inflammation and open sores inside the colon. The inflammation harms the lining of the colon, which leads to bleeding, production of pus, constant diarrhea, and pain.

There are currently no cures for ulcerative colitis, so the goal for existing medical therapy is to induce and maintain remission. The symptoms can go for months or even years. When not in remission, treatments focus on reducing the symptoms, and improving quality of life for the patients.

In serious cases, surgical removal of the colon and rectum may be suggested, though this obviously greatly impacts on quality of life. A glutamine supplement was studied, which may help in IBD cases.

Glutamine supplement study

E Joo, S Yamane, et al, researchers at the Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan, investigated a new glutamine supplement for treating ulcerated colitis. The supplement contains the amino acid glutamine, fiber, and oligosaccharide.

A glutamine supplement has a variety of biochemical roles in the body, including improving gastrointestinal function. Glutamine supplement may help protect the lining of the gastrointestinal tract, which is damaged by ulcerative colitis.

The researchers tested mice, in which they induced colitis. The mice were given either the glutamine supplement, or a placebo, for ten days. The animals’ body weight loss and the measurable activity of colitis were tested.

Results of glutamine supplement for colitis

The glutamine supplement group had some impressive results. Their body weight loss and disease activity index were significantly lower. Additionally, intestinal inflammation was reduced with the glutamine supplement group.

The study concluded that a glutamine supplement has an excellent potential for a new therapy for ulcerative colitis.

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There are currently no cures for ulcerative colitis, so the goal for existing medical therapy is to induce and maintain remission. The symptoms can go for months or even years. When not in remission,

L-glutamine Amino Acid and Depression

Is there a link between L-glutamine and depression?  Definitely!  It certainly appears that L-glutamine is a vital amino acid that increases positive outlook and relieves depression.  

L-glutamine is one of the major energy sources for the brain and without enough L-glutamine the brain relies on glucose for fuel which is why we crave sugar when we are stressed or sad.  Without enough fuel to function, the brain slumps and the result is a decrease in mental function, a sense of ‘the blues’ and a fundamental lack of motivation.

L-glutamine provides a healthy fuel for the whole body, not just the brain. Too much glucose can cause obesity, diabetes and many other diseases including cancers. Illness contributes to depression as well and it is important to keep the body healthy in order for the mind to be happy.  L-glutamine is a better fuel in this respect then glucose.

Connection between L-glutamine and depression may be in glucose balance

L-glutamine also helps relieve depression by being a more sustained, long burning fuel then glucose.  Glucose gives a large surge of energy that is inevitably followed by a crash that leaves the body craving more sugar and feeling depressed.  The result of this is addictive behaviour, a constant need to increase the amount of sugar ingested and that results in more feelings of depression.

Stress is also a frequent culprit for causes of depression.  Constant stress causes wear and tear on the whole body as a system, including the brain.  Stress also releases many hormones that result in feelings of unhappiness that can lead to long term depression. In order to heal from stress, the body needs to heal the damage done to its proteins and all of these damaged proteins can be synthesized from L-glutamine.  By taking L-glutamine to heal the damage caused by stress you can also prevent or help to recover from depression.

L-glutamine is a precursor to GABA – another relaxing amino acid

L-glutamine also enhances nervous system functions and is a precursor to the amino acid GABA.  GABA is an anxiety quelling amino acid and increased levels of GABA can help to prevent the stress from too much worry.  Worry can quickly lead to feelings of helplessness and depression.  L-glutamine helps by giving your body the building blocks to replenish its supply of GABA and gives the sense of competency to deal with anxiety and depression.

L-glutamine can be found in many high protein foods such as chicken, fish, beef, beans, dairy products, cabbage and beets. It can also be very useful to use a supplement to be sure to get all the L-glutamine you need to recover or prevent depression.

The author of this story, Michelle Carraway, is a freelance contributor to National Nutraceuticals’ online news portals, which include Medicinal Mushroom Information Center, Amino Acid Information Center, Vancouver Health News and Today’s Word of Wisdom.  The opinions are the writer’s own and the owner and publisher of the site assume no responsibility for the accuracy of the content. Our articles are for informational, educational and entertainment purposes only. Please do your own due diligence, verify any health claims by doing additional research and consult your doctor before starting any supplementation program or making any lifestyle changes, including changes to your medication and supplementation.






L-Glutamine for IBS (Irritable Bowel Syndrome)

L-Glutamine is essential in treating irritable bowel syndrome, also called IBS. L-Glutamine is the main source of energy for the cells that make up your intestinal lining. The cells that make up the lining of your intestines manufacture mucus that dictates the permeability of your intestine walls.  This is often referred to as ‘leaky gut syndrome’ and is associated with irritable bowel syndrome.  

IBS or irritable bowel syndrome is a disease that affects many people and it has a spectrum of symptoms that make it difficult to diagnose and very hard to treat.  Stress, antibiotics and various other factors have been noted to have been frequent factors in the onset of IBS.  These factors may also lower the amount of L-glutamine in the body and cause the intestines, an area of the body that requires L-glutamine to regulate and function, to go short.

L-Glutamine for IBS and other Health Benefits

The results of stress or other factors that can upset the flora of the intestine are that they can become damaged and they are unable to repair themselves without sufficient quantities of L-glutamine to repair them. Once the intestines are repaired, L-glutamine helps to keep them in a state that is less stressed, less permeable and in better health.

L-glutamine also absorbs water from the bowels and transports it into the cells of the body where it can be utilized properly, this stops diarrhea, a common complaint from people suffering from Irritable bowel syndrome.

Natural sources of L-glutamine include cabbage, beets, beef, chicken, fish, beans and dairy. If you choose to use a supplement, it can be beneficial to take L-glutamine a few hours before meals to give your intestines extra assistance.


 http://www.livestrong.com/article/431680-irritable-bowel-syndrome-l-glutamine/ 1



The author of this story, Michelle Carraway, is a freelance contributor to National Nutraceuticals’ online news portals, which include Medicinal Mushroom Information Center, Amino Acid Information Center, Vancouver Health News and Today’s Word of Wisdom.  The opinions are the writer’s own and the owner and publisher of the site assume no responsibility for the accuracy of the content. Our articles are for informational, educational and entertainment purposes only. Please do your own due diligence, verify any health claims by doing additional research and consult your doctor before starting any supplementation program or making any lifestyle changes, including changes to your medication and supplementation.