Tag Archives: chronic liver disease

Chronic Liver Disease Shows Amino Acid-Sulphur Deficiency

Turns out that your liver can benefit from the sulphur-containing amino acids methionine and cysteine. Health benefits of amino acids such as these are excellent, but this is especially true for those with liver disease. As it turns out, those with chronic liver disease actually show a pattern of sulphur deficiency, so both cysteine and methionine may help with this.

Advanced liver disease and methionine / cysteine amino acids

In advanced or chronic liver disease, the metabolism of the sulphur-containing aminos, such as methionine and cysteine, are is impaired (no difference in the amino acid taurine, however).

In a study by P Almasio, G Bianchi, et al., at the Clinica Medica R, Università di Palermo, in Italy, the researchers published their discoveries based on 60 people who had chronic liver disease. The results show a pattern of amino acid deficiency in these patients.

10 of the subjects were used a control because they were healthy, but the other 50 patients had chronic liver disease, which was proven via biopsy.

The breakdown of their liver disease impairments

Hypermethioninemia (an extreme amount of methionine) was present in only these cases:

10 cases compensated cirrhosis
10 cases decompensated cirrhosis

Plus there were:

30 cases chronic hepatitis

The results of this clinical trial showed cysteine, a metabolite of methionine metabolism, was “markedly reduced in patients with compensated chronic liver disease, while in advanced cirrhosis its concentration was within the normal range.”

Methionine is an essential amino acid, which means you can only get it through diet, particularly protein foods such as meats (chicken, beef, pork, lamb, plus fish and eggs). Also, cysteine is a non-essential amino acid, which means the body can produce this amino acid on its own. No differences were observed (in plasma levels) for the amino acid taurine between groups.

What was observed was how sulfur-containing amino acid metabolism was deranged and “possibly located at various steps along the trans-sulphuration pathway, is also present in mild forms of chronic liver disease.”

What this means is that a key marker for those with chronic liver disease is that sulphur-containing amino acids are deficient. This can be true for people suffering from decompensated cirrhosis), or hepatitis.

The study did not explain whether supplementing intake with cysteine or methionine would affect the—chronic liver disease–patients in a positive way or not, but it is good to know that both of these amino acids are in ample amounts when associated with healthy livers, yet levels are abnormal in diseased livers.

Reference:

http://www.ncbi.nlm.nih.gov/pubmed/8025302

Your Liver Benefits from Sulfur-Containing Amino Acids Methionine and Cysteine

The Amino Acid-Sulfur Deficiency Pattern Has Been Found in Human Chronic Liver Disease.

A study about advanced liver disease (chronic liver disease) demonstrates that the metabolism of sulfur-containing amino acids—like methionine and cysteine (but no difference in taurine)—is impaired.  A study by P Almasio, G Bianchi, et al., was done at the Clinica Medica R, Università di Palermo, in Italy. Their findings in 60 people with chronic liver disease from a clinical trial were fascinating.

Cysteine and Methionine Benefits Those Suffering from Chronic Liver Disease

In the study, 10 of the subjects were healthy (used as a control), whereas the other 50 patients had these chronic liver diseases (proven with biopsy):

30 cases of chronic hepatitis
10 cases of compensated cirrhosis
10 cases of decompensated cirrhosis
(hypermethioninemia—an extreme amount of methionine—was present in only these latter cases)

The results of this human clinical trial showed that cysteine, which is a metabolite of methionine metabolism, was “markedly reduced in patients with compensated chronic liver disease, while in advanced cirrhosis its concentration was within the normal range.”

Methionine is an essential amino acid (meaning it must be gotten through dietary proteins like beef, chicken, fish, or eggs since these proteins provide all 22 amino acids). Cysteine is a non-essential amino acid (meaning your body can produce it on its own rather than needing dietary supplementation). The amino acid taurine (in plasma levels), however, were observed between the different groups yet no differences were observed.

What was discovered was the derangement in sulfur-containing amino acid metabolism “possibly located at various steps along the trans-sulphuration pathway, is also present in mild forms of chronic liver disease.”

Methionine Benefits

The bottom line is that chronic liver disease proves out a marked deficiency of sulfur-containing amino acids in the people suffering from it for cirrhosis (except in decompensated cirrhosis), or even hepatitis. This study did not provide information on whether supplementation of methionine or cysteine would positively affect these patients with chronic liver disease; however, that these amino acids are associated with healthy livers, and abnormal in diseased livers, is certainly telling.

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Reference:

http://www.ncbi.nlm.nih.gov/pubmed/8025302