Tag Archives: anticancer

Antiaging Treatments – GABA Amino Acid, Lifestyle, or Ikaria?

Antiaging treatments have included creams and lotions, or even food and potions. People and even experts say things like… drink this, eat that, live here, go there, exercise more, eat less, eat healthier, live in the Andes mountains, take this supplement (like GABA amino acid), take that supplement (like Reishi medicinal mushrooms). 

Antiaging may even include a move to Ikaria (known as Icaria, a Greek island) like Stamatis Moraitis did, according to the New York Times article entitled: The Island Where People Forget to Die, discussing how he overcame cancer merely by choosing to move back home and altering his lifestyle. Stamatis Moraitis is a centenarian, meaning he is over one hundred years old, and still alive and well, sharp as a tack, and happy and healthy.

Anti-aging techniques and treatments for some people may or may not include GABA amino acid supplements, or a lot of small changes in lifestyle (or major ones, depending), but one thing is for sure… it is not usually just one thing, but a combination of many. Longevity can include heredity/genetics as well as environmental factors.

Longevity and aging gracefully may include supplements like GABA amino acid

Aging is associated with the body’s cells breaking down over time and not functioning at the levels that they used to when people were younger. Cells die and are not regenerated the same way. To overcome physical or biological entropy it is often recommended that not just living somewhere or eating a certain way is key (although both can promote health benefits, depending on the person), but sometimes changing all the “little things” in life so that they add up to become the “big things” all by themselves.

Little things can include dietary changes, exercise regimens, breathing techniques and yoga, distressing, skipping fast food and eating fresh fruit instead, and even taking GABA amino acid supplements.

What can GABA amino acid supplements do for you?

According to a demographic study by SV Ukraintseva, KG Arbeev, et al., on antiaging treatments, many of them legally prescribed for thirty years, more or less, some of the “most common of the relevant medicines are nootropic piracetam, gamma-aminobutyric acid (GABA), selegiline, Ginkgo biloba, pentoxifylline, cerebrolysin, solcoseryl, ergoloid, vinpocetin, sertraline, and estrogens, among others.” GABA amino acid is one of these popular items used for supplementation and antiaging.

GABA amino acid can have a variety of effects on your body, mind, and health. A general overview is covered in the article What Can GABA Amino Acid Do For Me?

GABA amino acid is also used to feel better, especially when one is in pain. Kill the Pain with Amino Acid GABA – Gamma-aminobutyric acid: Nature’s Pain Killer is an article on this very topic. Isn’t part of growing old feeling good and not being subject constantly to joints and inflammation, aches, and pains?

Additionally, protecting your brain and stimulating your senses and memory are key factors. Learning a language, or even knowing what GABA amino acid supplements can do to help your brain and memory or cognition can be read about here in Amino Acid GABA Vital For Normal Brain Activity And Memory. Memory is often a problem with dementia and Alzheimer’s as one gets older.

Although GABA amino acid is not the cure-all for all ailments, it is one of the many “little things” one can do to reduce pain, combat aging and restore a sense of youthfulness, health and wellness, and memory abilities. Perhaps it could still be included in many peoples’ little box of secret weapons against aging.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/15246996

http://www.nytimes.com/2012/10/28/magazine/the-island-where-people-forget-to-die.html?smid=fb-share&_r=0

Arginine Slows Proliferation And Growth Of Lung Cancer Cells

Some promising news about the treatment of lung cancer was published in the American Journal of Cancer Research. The essential amino acid arginine is being developed into an effective anti-cancer agent. Synthesized arginine/albumin microspheres have been designed to combat lung cancer.

Lung cancer is one of the leading causes of cancer-related death. As with all cancers, early detection is the best hope for successful treatment. However, the early stages of lung cancer usually do not produce symptoms. As the cancer advances, symptoms develop, including coughing, wheezing, and coughing up bloody mucus.

Treatment can include surgery, chemotherapy, and radiation. Recent clinical trials have focused on endobronchial intratumoral chemotherapy, which is the direct injection of the drug into the tumor.

Arginine, an essential amino acid, also known as L-arginine, is already proved to inhibit cancer cell proliferation in various cancers, including lung, breast, and gastric cancer cell lines when an appropriate dose is delivered. High concentrations of arginine incudes cancer cell death. Arginine also assembles into clusters to kill cancer cells.

Researchers (HY Lee, KA Mohammed, et al) from the University of Florida, USA, developed a study to investigate the delivery method of L-arginine in endobronchial intratumoral chemotherapy. They designed arginine/albumin microspheres to deliver high concentrations of arginine to the tumors.

Microspheres of synthesized arginine prevent lung cancer cells proliferating

The researchers tested arginine/albumin microspheres on A549, a human lung carcinoma cell line. And arginine/albumin mesospheres (AAMS) were synthesized which promotes arginine clusters. These AAMS consisted of 50% arginine and 50% bovine serum albumin. The minute microspheres were solidified in a centrifuge tube.

This in vitro study produced very positive results. The arginine significantly inhibited cell proliferation, cell migration, and tumor growth of the lung cancer cells. The synthesized AAMS were more effective than freely released arginine, indicating that AAMS could become an ideal delivery vehicle for lung cancer treatments.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/23841026

Whey Protein: The Superfood that Slows Aging – Amino Acids and Glutathione

Lots of chatter has been going on about so-called Superfoods these days, such as spinach being packed with nutrition, when vegetables like swiss chard have far more nutrients ounce-for-ounce. Similarly, there is chatter about what is or is not a Superfood, like whey protein, since it is considered a supplement rather than a whole food. However, according to Dr. Mercola—whom has written on the “Top 7 Foods That Slow Your Aging” it is whey protein that is the exception and should be added to the list. Why? Although there are a number of reasons, amino acids plus glutathione are .

Glutathione is an antioxidant produced from other amino acids. Additionally, increasing glutathione levels through food containing those amino acids brings a host of health benefits. Whey protein is one way to do this.

Anti-aging health benefits of glutathione & amino acids from whey protein

Dr. Mercola says that whey can “increase your body’s stores of the antioxidant glutathione, or GSH.” Additionally, telomeres in your DNA are in every cell in your body, and they get shorter with age; glutathione increases the integrity of telomeres since free radicals (that cause DNA mutations) tend to damage them.

Glutathione keeps us healthy. GSH levels tend to drop in people who have oxidative stress-related health issues, such as diseases like AIDS or cancer. Patients get sicker after glutathione levels drop. Eating whey can help keep your glutathione levels up.

Glutathione supplements are NOT recommended, but precursors instead

You cannot ingest glutathione directly, however, for it is actually made inside your cells from the amino acid precursors: glycine, cystine, and glutamate. So no need to take glutathione supplements… just eat foods—like whey protein—that can help your body manufacture the antioxidant glutathione you need to fight the aging process and keep your telomeres intact.

Dr. Mercola states that biologists are now saying that lengthening telomeres actually may REVERSE aging, and a flurry of excitement is spinning around this concept in medical and research circles on antiaging methods.

Mercola states that the “best way to increase and maintain your GSH (glutathione) levels is to make sure your diet includes foods (such as animal foods and eggs) rich in the sulfur amino acids your cells need to synthesize glutathione. Whey protein is the easiest and most convenient way to do this.”

Just be sure, Mercola warns, that the whey protein you consume is not just any variety, because it needs to be “high quality and very carefully processed from grass fed organic cows to preserve the fragile amino acid precursors.”

It comes down to the quality of food that we are putting into our bodies, and ensuring that we take care of ourselves daily, in order to help reverse the aging process.

Reference:

http://articles.mercola.com/sites/articles/archive/2010/02/27/top-7-foods-that-slow-your-aging.aspx

L-arginine Prevents Gastric Cancer Cell Growth

More interesting news about the anti-cancer effects of the essential amino acid L-arginine (or simply, arginine). A European study investigated the effects of L-arginine on tumor cell growth on human gastric cancer cell lines. Would L-arginine promote cancer cell death?

Gastric, or stomach, cancers have a poor prognosis because they develop slowly over many years without producing symptoms. By the time symptoms occur, the cancer may have spread, or metastasized, which is much more difficult to treat. The 5-year survival rate is only 5-15%.

Most stomach cancers are adenocarcinomas, which develop from the cells lining the stomach.  Smoking irritates these cells, and smoking greatly increases the risk of developing gastric cancer. Eating a diet high in antioxidant-rich foods, such as fresh berries, could reduce the risk.

S Nanthakumaran, I Brown, et al, researchers at the University of Aberdeen’s College of Life Sciences and Medicine, in Scotland, UK, developed a study on immunonutrition. Immunonutrition is the development of nutritional components that favorably affect the immune function.

The researchers wanted to examine the effects of the amino acid L-arginine on tumor cell growth, cancer cell invasion, and the cancer’s effect on gene expression.

Can L-arginine help treat stomach cancer?

L-arginine is already proven to enhance the immune system, and reduce infectious complications in patients undergoing gastrointestinal surgery.  Healthy people are usually able to synthesize enough L-arginine in their bodies. However, L-arginine supplements are useful for people with surgical or other traumas.

In order study L-arginine’s effect on tumor cells, the researchers grew human gastric cancer cell lines in vitro. Different concentrations of L-arginine were tested.

L-arginine caused the cancer cells to die, by inducing cancer cell apoptosis  (programmed cell death).The researchers discovered cell growth inhibition was caused by the L-arginine increasing the expression of a significant protein: caspase 8. Caspases play an essential role in promoting apoptosis.

L-arginine, therefore, has the potential of being developed into an anti-cancer agent.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/19036482/