Tag Archives: anti-inflammatory

Arginine for Inflammation and Erectile Dysfunction

For men, arginine may pose as almost a miracle amino acid for inflammation and erectile dysfunction, but one should be wary that arginine combined with other amino acids, protein, and lifestyle changes are more likely the answer.

Arginine, has been getting a lot of attention for it can be an amazing anti-aging amino acid. It also may be useful for graying hair, loss of hair, heart disease, preventing heart failure, and possibly inflammation.

This is where pieces of the arginine amino acid puzzle starts to thicken.  Inflammation and erectile dysfunction are two problems often linked together as exemplified by the article “Reduction of Inflammation Improves Endothelial Function and ED” whereby “minimizing infection and inflammation throughout the body, including avoiding fat accumulation, should improve both vascular and erectile health.”

The link may be attributed to arginine being needed by the body to make nitric oxide.

Because nitric oxide is crucial for maintaining healthy blood pressure, it also helps prevent atherosclerosis, and plays a role in modulating immune system function. In addition, nitric oxide regulates several processes in the body, including fat and glucose metabolism.

Researchers found that inhibiting nitric oxide production was associated with fat gain while stimulating nitric oxide secretion was correlated with enhanced lipolysis, or fat breakdown, according to research published in the September 2006 issue of the Journal of Nutritional Biochemistry.

The best part about nitric oxide is that it is readily available on a sunny day.

Is Nitric Oxide the Cure for Inflammation and ED?

There is some strong evidence that indicates nitric oxide may help both inflammation and ED. In the study, “Role of Nitric Oxide in Inflammatory Diseases” they concluded NO (nitric oxide) inhibitors “represent important therapeutic advance in the management of inflammatory diseases”.

Additionally, the amino acid L-arginine stimulates nitric oxide, which releases “growth hormone, insulin, and other substances in the body.” Prescription drugs also may contribute to maintain the nitric oxide in the body, which can also help prevent erectile dysfunction.

In conclusion, when it comes to adults, and particularly men of industrialized countries, the issue may not be so much about consuming enough protein and amino acids, the concern might be to see the bigger picture and rooting out the problem of inflammation and erectile dysfunction, instead of just ‘curing’ this challenge with a quick fix. Certainly stress is one factor, lack of sleep another, but also being mindful of our diets and exercise.

References:

http://www.medscape.com/viewarticle/761122_18

http://articles.mercola.com/sites/articles/archive/2013/07/15/sun-exposure.aspx

http://www.livestrong.com/article/233939-l-arginine-weight-loss/

http://www.ncbi.nlm.nih.gov/pubmed/18236016

http://www.webmd.com/vitamins-supplements/ingredientmono-875-L-ARGININE.aspx?activeIngredientId=875&activeIngredientName=L-ARGININE

Anti-Inflammatory Effect of Amino Acids Cysteine, Glycine and Histidine

Inflammation in the body is like fire in the veins! But can inflammation be “cooled off” by the amino acids cysteine, glycine, and histidine? Inflammation is characterized as the bodily response of vascular tissues to unsafe stimuli. 

Such stimuli may include pathogens, irritants or damaged cells. Symptoms can vary in cases of inflammation, but the most common signs are redness, heat, swelling, pain, and loss of function in the affected area.

Because inflammation is a discomfort that affects a majority of the population at one time or another, researchers at Yamaguchi University Graduate School of Medicine in Japan set out to examine the anti-inflammatory effects of the amino acids cysteine, glycine and histidine.

Researchers S. Hasegawa, et al., report that nuclear factor-kappa B is a system that regulates endothelial activation. They explain that nuclear factor-kappa B is induced by tumor necrosis factor-alpha in vascular endothelial cells, and it is this process that can lead to inflammation and disorders such as atherosclerosis.

The researchers wanted to test the anti-inflammatory effects in coronary endothelial cells since results from previous studies ended inconclusively. They hypothesize that amino acids cysteine, glycine and histidine would produce inhibitory effects on nuclear factor-kappa B activation in human coronary arterial endothelial cells.

The effect of amino acids cysteine, glycine and histidine on inflammation in endothelial cells

For the study Hasegawa et al. took human coronary arterial endothelial cell cultures and treated them with either alanine, cysteine, glycine and histidine amino acids. They stimulated the cultures with 2 ng/mL of tumour necrosis factor-alpha before taking out nuclear extracts to determine their concentrations of proteins and nuclear factor-kappa B.

They found that without treatment, the cultures showed significant activation of nuclear factor-kappa B. But with pretreatment of cysteine, glycine and histidine, nuclear factor-kappa B activation was inhibited significantly in the coronary endothelial cells. Alanine did not have an effect on the activation, demonstrating no anti-inflammatory properties.

Overall, cysteine showed the most inhibiting effects out of the tested amino acids at any concentration. They also found that the amino acids inhibited E-selectin expression, a cell adhesion molecule that plays an important role in inflammation.

Based on these results, the researchers conclude that cysteine, glycine and histidine can help reduce inflammation to the endothelial cells.

Source:

http://www.ncbi.nlm.nih.gov/pubmed/22236003

4 Amino Acids: Natural Painkiller-Analgesic and Anti-Inflammatory

Amino acids, like L-isoleucine, may act as a natural painkiller. There are actually a number of amino acids that are involved, and a study was done regarding prostaglandin to see just how much of an analgesic (natural painkiller) and anti-inflammatory these really are.

In order to understand the study done on the amino acids and how they deal with inflammation and work as an analgesic, or natural painkiller, we must understand prostaglandin.

Prostaglandins are on-site lipid compounds work like Aspirin. They are enzymatically derived from fatty acids to serve important bodily functions. Prostaglandins work in a number of ways, but one of them is as a natural painkiller, or analgesic. Analgesics are usually drugs that help your body achieve analgesia (relief from pain).

When injured or ill, prostaglandins—from the 4 amino acids or otherwise—are not secreted from a gland, but are chemically made on-site and used specifically where needed. One of their purposes is to control inflammation.

Amino acids – natural painkiller and anti-inflammatory properties

According to a study done by E Ricciotti and GA FitzGerald on prostaglandins, they act as a natural painkiller and carry an anti-inflammatory response. They said, “prostaglandins may function in both the promotion and resolution of inflammation.” Amino acids can also have an anti-inflammatory response.

In a separate study, RN Saxena, VK Pendse, and NK Khanna “Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only.”

However, it was L-isoleucine that exhibited a prolonged analgesic (natural painkiller) effect. In the meantime, DL-isoleucine had a short-lasting effect.

Luckily the amino acids caused no gastric ulceration or acute toxicity in the doses that effectively suppresses inflammation. Their final assessment on these natural painkiller amino acids were that the “anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.”

References:

http://www.ncbi.nlm.nih.gov/pubmed/6335992

http://www.ncbi.nlm.nih.gov/pubmed/21508345