Tag Archives: alternative treatment

Tyrosine and Tyrosine Kinase for Thyroid Cancer

Tyrosine amino acid has a number of health benefits; however, it may not be helpful for skin cancer. That said, related to this is the enzyme tyrosine kinase, which is used to treat thyroid cancer according to some research done at the Department of Medicine at Baylor College of Medicine in Houston, Texas.

Thyroid cancer statistics from the American Cancer Society includes:

“About 62,980 new cases of thyroid cancer (47,790 in women, and 15,190 in men)
“About 1,890 deaths from thyroid cancer (1,060 women and 830 men)
“Thyroid cancer is commonly diagnosed at a younger age than most other adult cancers. Nearly 2 out of 3 cases are found in people younger than 55 years of age. About 2% of thyroid cancers occur in children and teens.”

Although tyrosine, an essential amino acid (which means your body produces it on its own rather than relying on diet alone). Protein foods like meats, eggs, and fish provide all 22 amino acids. However, the enzyme tyrosine kinase has been researched as a helpful supplement for treating thyroid cancer. Standards for the treatment are needed, but this medical study below examples how tyrosine kinase is an effective cancer treatment.

Tyrosine kinase as a thyroid cancer treatment

Tyrosine kinase is an enzyme that transfers a phosphate group from ATP over to proteins within cells, which attaches to the amino acid tyrosine on these proteins. The enzyme also attaches to other amino acid such as threonine or serine, but tyrosine kinases have a special ability to mutate to an “on” position. This allows growth of the cells to happen, which is extremely important for treating cancer.

These are called tyrosine kinase inhibitors and can help in cancer treatments, including for thyroid cancer.

A study by AA Carhill, ME Cabanillas, et al., in Houston’s Division of Endocrinology, Diabetes, and Metabolism, have studied tyrosine kinase inhibitor therapy in regards to creating standards for treating patients with thyroid cancer.

The researchers needed a “systematic approach to the clinical application of these agents in order to improve patient safety and monitoring promote consistency among providers, and ensure compliance with both institutional and industry standards.”

Their conclusions were based on the tyrosine kinase inhibitor applications they reviewed, including professional guidelines for thyroid cancer, plus reports, trials, and articles, etc., all published in the prior decade. They also included older studies for tyrosine kinase inhibitors.

The research allowed them to develop a “standardized approach related to prescribing commercially available tyrosine kinase inhibitors … for patients with advanced thyroid cancer.”

It is already important to note the already-established knowledge of enzyme-based tyrosine kinase inhibitor therapy, just as tyrosine and other amino acids are well known for their health benefits, but to help develop a standard for thyroid cancer therapy using enzymes was needed, and the void met.

References:

http://www.ncbi.nlm.nih.gov/pubmed/23185034

http://en.wikipedia.org/wiki/Tyrosine_kinase

http://www.cancer.org/cancer/thyroidcancer/detailedguide/thyroid-cancer-key-statistics

What are Carnitine and Carnosine Amino Acids Used for?

There are two amino acids that often get mixed up: carnitine and carnosine. What are they and how do they differ? Amino acids are the building blocks of proteins. Normally, when you eat proteins your body breaks them down into their basic units, called amino acids. Then your body puts them back together in a new way to build protein in your body, such as muscles and organs, and it is used for other bodily functions as well.

Carnitine is an essential amino acid, meaning that your body cannot produce it on its own, so it must be gotten through diet, specifically from protein foods (meats, fish, and eggs have all 22 common amino acids), but can also be taken as an amino acid supplement.

Carnosine is a non-essential amino acid, which means that your body produces it on its own; therefore, it is not usually needed as a supplement.

Both carnitine and carnosine can be taken as supplements, but be careful doing so without checking with your doctor (whether separately or together) first since they can have side effects, especially if you are taking certain medications. Normal amounts of carnitine and carnosine that are gotten through food do not apply.

Carnitine and carnosine are usually connected with other amino acids:

Carnitine is synthesized from the amino acids methionine and lysine.
Carnosine is made from the amino acids histidine and alanine.

Carnitine and carnosine health benefits

Carnitine helps the body burn fat by transporting fatty acids, and it also flushes toxins out of the mitochondria within cells. Carnitine is found in concentrations within the cardiac muscle and skeletal muscles. It also could possibly aid in reducing symptoms of people with an overactive thyroid. People who have diabetic neuropathy may also find some pain relief, thanks to carnitine.

Carnosine works differently than carnitine. In effect, it is an antioxidant. It functions within the brain, nervous system, and skeletal muscles. Interestingly, this amino acid can help remove excess zinc and copper out of the body in a process known as chelation. It may also help with cataracts and speed up wound healing.

Carnitine and carnosine are complimentary for diseases

Carnitine and carnosine both have anti-aging effects, plus reduces the speed of memory loss in Alzheimer’s disease (AD) age-related patients.

Another area is autism, where the carnitine and carnosine both function to help autism as an alternative treatment. When comparing these two amino acids for autism treatment, Michael Chez, M.D., et al. (Nov 2002 Journal of Child Neurology) and Dan Rossignol, M.D., (Oct 2009 Clinical Psychiatry), reported that carnitine got a grade “B” for improving symptoms of autism, while carnosine got a grade “C” for improving communication and behavior.

These two amino acids also help improve cardiovascular function, but they do so in different ways. Carnitine reduces the symptoms of heart angina and peripheral vascular disease. Carnosine reduces the risk for developing atherosclerosis plus can help reduce cholesterol.

An important note: some physicians believe people should avoid taking D-carnitine because it can interfere with L-carnitine, which is naturally found in the body. Because of this, you should ask your physician before taking both carnitine and carnosine as supplements.

Reference:

http://www.livestrong.com/article/493759-carnosine-vs-carnitine/