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Glutamine Supplement: New Therapy For Ulcerative Colitis?

An animal study from Japan has found good news for ulcerative colitis sufferers. There is a possible new supplement, enriched with L-glutamine amino acid available on the market. This glutamine supplement could improve symptoms of colitis.

Ulcerative colitis is a chronic, long lasting disease. It’s an autoimmune disease, one of the forms of inflammatory bowel disease (IBD).  Crohn’s disease is the other form of IBD.

Ulcerative colitis is a very painful condition which results in inflammation and open sores inside the colon. The inflammation harms the lining of the colon, which leads to bleeding, production of pus, constant diarrhea, and pain.

There are currently no cures for ulcerative colitis, so the goal for existing medical therapy is to induce and maintain remission. The symptoms can go for months or even years. When not in remission, treatments focus on reducing the symptoms, and improving quality of life for the patients.

In serious cases, surgical removal of the colon and rectum may be suggested, though this obviously greatly impacts on quality of life. A glutamine supplement was studied, which may help in IBD cases.

Glutamine supplement study

E Joo, S Yamane, et al, researchers at the Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan, investigated a new glutamine supplement for treating ulcerated colitis. The supplement contains the amino acid glutamine, fiber, and oligosaccharide.

A glutamine supplement has a variety of biochemical roles in the body, including improving gastrointestinal function. Glutamine supplement may help protect the lining of the gastrointestinal tract, which is damaged by ulcerative colitis.

The researchers tested mice, in which they induced colitis. The mice were given either the glutamine supplement, or a placebo, for ten days. The animals’ body weight loss and the measurable activity of colitis were tested.

Results of glutamine supplement for colitis

The glutamine supplement group had some impressive results. Their body weight loss and disease activity index were significantly lower. Additionally, intestinal inflammation was reduced with the glutamine supplement group.

The study concluded that a glutamine supplement has an excellent potential for a new therapy for ulcerative colitis.

Please remember to visit our other health news portals, Medicinal Mushroom Information Center at http://medicinalmushroominfo.com Vancouver Health News at http://VancouverHealthNews.ca and http://todayswordofwisdom.com.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/23274091

There are currently no cures for ulcerative colitis, so the goal for existing medical therapy is to induce and maintain remission. The symptoms can go for months or even years. When not in remission,

Amino Acid Leucine Supplement Burns Fat, Fights Obesity

he amino acid Leucine is a popular dietary supplement, used in many sports drinks to promote muscle growth and endurance. But is it possible that Leucine supplement burns fat and fights obesity? A study from the University of Tennessee looked into the effects of a leucine/Vitamin B6 supplement on preventing the devastating effects of obesity.

Obesity rates are so high now that the World Health Organization considers it to be an epidemic. It increases the likelihood of developing many serious health problems. So what can we do about it?

Researchers Michael Zemel and Antje Bruckbauer (University of Tennessee) developed a clinical trial to examine various factors including oxidative stress. They hoped to prove the effectiveness of a leucine/Vitamin B6 supplement (NuFit active blend) in improving fat_oxidation. Fat oxidation is best described as burning fat, or energy, in our bodies. And if we don’t burn the fat, but instead store too much fat—if we are obese–we will develop oxidative_stress.

Oxidative stress is thought to be involved in the development many diseases, including cancer, and heart failure. Targeting obesity therefore significantly reduces the risk of developing a wide variety of health problems.

The four week clinical trial involved 20 obese subjects. They were given either the supplement containing the amino acid leucine or a placebo three times every day. The NuFit Leucine supplement was dissolved into black tea to disguise the flavor.

Leucine is widely available, found in foods like soybeans, beef, and peanuts. It’s also a popular food additive, and is classified as a flavor enhancer.

Amino acid leucine increases fat oxidation and burns fat

The study had impressive results. The NuFit Leucine supplement increased fat oxidation, and significantly reduce oxidative stress. It also led to a 43% decrease in triglyceride content. This means the supplement tested will be a valuable method of managing and even preventing obesity.

Sources:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397351/

Amino Acids and Diabetes — Drinking Amino Acids Before Meals Controls Blood Sugar

here is new and exciting research regarding amino acids and diabetes. Drinking a protein/amino acid mix before eating can help keep your blood sugar low, finds a Swedish study. This is great news for diabetics, and people at risk for developing diabetes.

Type 2 Diabetes is a metabolic disease which causes high blood sugar. It already affects millions of people. Being overweight is one of the main risk factors to developing this disease, and the current obesity crisis—which the World Health Organization calls an epidemic—means more people are being diagnosed as diabetic every day.

Diabetics often suffer from hyperglycemia , which means they have an excessive amount of glucose in their blood plasma.

People with high blood sugars can develop very serious complications, including kidney damage, neurological damage, cardiovascular disease, damage to the retina or damage to feet and legs. So diabetics must control their blood sugar. And monitoring your blood sugar is an important way to reduce your risk of developing diabetes.

Amino acids and diabetes — amino acid drink reduces blood sugars after meals

A study to evaluate the effects of pre-meal drinks on blood sugar was developed by Ulrika Gunnerud, Cornelia Heinzle, et al, researchers with the Department of Applied Nutrition and Food Chemistry, at Lund University in Sweden.

They investigated the effect of consuming drinks containing protein and a mixture of five amino acids, before eating. The amino acids studied were isoleucine, leucine, lysine, threonine and valine.

14 healthy, non-smoking volunteers took part in this randomized, single blind trial. Their blood was tested after fasting, and then again after they had eaten. They were given the pre-meal protein, amino acid drink, and then given a ham sandwich. The drink and sandwich were consumed within 12 minutes.

Amino acids and diabetes — blood glucose levels reduced by almost 50%

Researchers found that starting a meal by drinking whey or soy protein with amino acids significantly reduced the post-meal blood sugar—by up to 47%.

The study concluded that using specific proteins and amino acids in pre-meal drinks could be a new strategy to help diabetics reduce high blood sugar.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/23028596

L-Carnosine Benefits: Can L-carnosine Become the Next Wonder Drug?

Found in abundance in muscles and the brain, the dipeptide L-carnosine is an organic compound comprised of the amino acids histidine and beta-alanine. Because of the various ways L-carnosine can benefit cellular activity, such as slowing down the growth of cataracts and certain tumour cells, researchers at Aston University in Birmingham decided to study the mechanisms behind how L-carnosine works.

In doing so, they believe that it could lead to breakthroughs in L-carnosine helping treat and prevent age-related ailments such as Alzheimer’s, Parkinson’s, type 2 diabetes and cancer.

Study for L-carnosine for health benefits, numerous diseases, even anti-aging

Scientists Alan Hipkiss, Stephanie Cartwright, Clare Bromley, Stephane Gross and Roslyn Bill believe that L-carnosine slows down age-related biological disturbances through energy metabolism or proteostasis, which is a type of protein stabilization process. Since L-carnosine also acts as an antioxidant, it has the potential to be used as a drug that can target multiple diseases.

They report that L-carnosine can act as a compound to combine the heavy metal that causes cell damage in the system. In doing so, L-carnosine will effective prevent lipids, proteins and DNA from undergoing age-related damage (antiaging properties).

The researchers recall another recent study that supports the theory that L-carnosine can improve cognition in people living with schizophrenia.

For Alzheimer’s disease, L-carnosine can act as a neuroprotective agent and has been shown to inhibit problems in the mitochondria. The dipeptide can also eliminate mutated polypeptides and stimulate the production of stress proteins that will further work to rebalance the system.

Overall, the researchers are very hopeful that the antioxidant and anti-senescence qualities of L-carnosine can greatly help cell deterioration due to old age. They reviewed studies that show L-carnosine can help slow cells that cause cancer, Alzheimer’s disease, Parkinson’s disease and alleviate symptoms of diabetes.

More comprehensive studies will have to be completed but the outlook is promising that L-carnosine can be an effective form of treatment for a variety of health problems.

Source:

http://www.ncbi.nlm.nih.gov/pubmed/23442334

Glycine Metabolism: Cancer Targeting Treatment?

Are we now able to peek into dangerous areas, like cancer, that would normally kill us? Scientists are having a look at glycine metabolism and its role in cancer growth. Researchers in Boston investigated the mutations cells undergo when healthy cells are mutated into cancer cells, and looked into possible ways of targeting these cancer cells.

Cancer occurs when previously healthy cells mutate, proliferating—replicating–rapidly. In fact, the definition of cancer is a malignant neoplasm, which refers to a group of diseases involving unregulated cell growth. The cancer cells divide and grow uncontrollably, forming malignant tumors which are often fatal. Rapidly proliferating cancer cells can spread to other parts of the body through the bloodstream or lymphatic system.

Very simply put, cancer can spread so rapidly because cancer cells reprogram normal, healthy cells. Mohit Jain, Roland Nilsson, et al, researchers with Harvard Medical School, Boston, USA, wanted to examine this metabolic reprogramming of cancer cells.

They studied 60 well-characterized human cancer cell lines, from nine common tumor types, to characterize cancer cell metabolism. The researchers profiled the cellular consumption and release of over 200 metabolites, the molecules which are necessary for metabolism.

Link between glycine metabolism and cancer cells

In the in vitro experiment, cancer cell lines were cultured, and their metabolites were measured. The researchers found a significant correlation between glycine consumption and cancer cell proliferation.

Glycine is a non-essential amino acid, which can be synthesized by our bodies. In the study, glycine was consumed by rapidly proliferating cells, and released by slowly proliferating cells. This means that glycine is demanded by the cancer cells. The glycine consumption was pronounced in ovarian, colon, and melanoma tumor cells.

The researchers discovered that the glycine biosynthetic pathway was closely linked to cancer cell proliferation, meaning that the cancer was relying on glycine to spread. This increased reliance could make the cancer cells metabolically vulnerable to specific targeting.

The study concluded that this metabolism of glycine could be used to target the rapidly proliferating cancer cells, possibly becoming a new anti-cancer treatment.

Sources:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526189/

Low Phenylalanine Diet and Cancer Patients

More information on the incredibly complex nature of cancer. Diets which limit tumor growth in animal models did not have the same positive effect on humans in a European pilot study. Diets without enough protein (that provide amino acids) like junk food that have low tyrosine and low phenylalanine were studied…

Advanced cancer is cancer which has spread, or metastasized, and may no longer be responding to treatment. Some cancers, such as brain cancers, are considered advanced cancer even if they haven’t spread. The cancer is not curable at this stage.

There are some treatment options, however, which focus on controlling the cancer and managing cancer symptoms, so the patient can feel as good as possible for as long as possible. Limiting the spread of cancer is one of the goals, including controlling tumor growth.

Low tyrosine and low phenylalanine diets

Researchers M Harvie, I Campbell, et al, with the University Department of Medical Oncology, South Manchester University Hospitals NHS Trust, Manchester, UK, hoped there would be a correlation between the results of an animal trial and a human trial in regards to low tyrosine and low phenylalanine.

A low tyrosine and low phenylalanine diet was successful in limiting tumor growth in animal models. These are both amino acids. Tyrosine is made in the body from phenylalanine, and is crucial to general metabolism. It has a strong antidepressant effect.

The researchers developed a pilot study to test the low tyrosine and low phenylalanine diet, which was offered to human volunteers with advanced cancer. Three patients with metastatic melanoma and three patients with metastatic breast cancer agreed to try the diet for one month.

Results were disappointing. All patients experienced negative side effects. They reported increased levels of anxiety and depression due to the low tyrosine diet. Some patients also lost weight. There was a slight increase in white cell counts, but not significantly.

The researchers concluded that low tyrosine and low phenylalanine diets are not a viable treatment for people with advanced cancer.

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/12028515

List of 9 Essential Amino Acids in Eggs

Eggs are a protein food that are jam-packed with 9 essential amino acids for your health. Not only do eggs help feed your brain, improve your eyes, are a high source of biotin plus vitamin D, but they also have more protein than any meat.

My mom was told by her naturopathic doctor to eat 4 eggs per day that are high in omega-3’s. This is, of course, to help her macular degeneration. The Lutein and zeaxanthin in eggs may reduce the risk of losing your eyesight due to macular degeneration. So far it seems to be helping her as the degeneration has already slowed or stopped.

The 9 essential amino acids in eggs are listed below, but first, a quick primer on essential versus non-essential amino acids and what that means…

Essential amino acids vs. non-essential amino acids

“Essential” does not mean necessary, but rather that the 9 essential amino acids must be gotten through diet. “Non-essential” means that your body can produce the amino acids on its own, without dietary supplementation.

Sometimes the body is deficient in its ability to make amino acids, and in severe cases it can cause diseases or health problems. In cases where the 9 essential amino acids can come from the food we eat, it is usually enough for our bodies to produce what it needs to survive, and indeed, thrive!

9 essential amino acids in eggs

The list of 9 essential amino acids (plus the list of non-essential aminos) found in eggs and other proteins like beef, chicken, and fish, include:

Essential Nonessential
Histidine Alanine
Isoleucine Arginine
Leucine Aspartic acid
Lysine Cysteine
Methionine Glutamic acid
Phenylalanine Glutamine
Threonine Glycine
Tryptophan Proline
Valine Serine
Tyrosine
Asparagine
Selenocysteine

Each of these 9 essential amino acids are good for different purposes in the human body. Please check out each one of them in other articles that other authors and I have written on this website. And remember, eggs are a near-perfect protein, can be eaten whole, raw or cooked in a variety of ways, and contain all 9 essential amino acids and 12 non-essential amino acids combined!

Please remember to visit our other health news portals, Medicinal Mushroom Information Center at http://medicinalmushroominfo.com Vancouver Health News at http://VancouverHealthNews.ca and http://todayswordofwisdom.com.

Reference:

http://articles.mercola.com/sites/articles/archive/2010/02/27/top-7-foods-that-slow-your-aging.aspx

www.ncbi.nlm.nih.gov/pubmed/19759170

L-Theanine Health Benefits — Ease Anxiety, Enhance Mood, Prevent Strokes

L-Theanine is an analog of the non-essential amino acid, glutamate. This particular amino acid is naturally found in (Camellia sinensis) or what is more commonly known as the tea plant. It is credited as the main natural ingredient that gives green tea its soothing quality. It may also be found in mushrooms specifically in bay boletes (Boletus badius).

Widely known for its relaxing effect, L-Theanine is made available in supplements and as an ingredient in beverages other than green tea, to ease anxiety and enhance mood. An article in the LA Times at http://articles.latimes.com/2009/may/04/health/he-theanine4 points out that though many drinks are marketed for their energy boosting properties, there are times when that boost is not exactly what people need. In fact, Dr. Michael Breus of the Huffington post at http://www.huffingtonpost.com/dr-michael-j-breus/energy-drinks-health_b_1496915.html outlines some of the side effects of these energy drinks including anxiety, restlessness, heart palpitations and insomnia.

Sometimes people just want the ability to focus, a bit of calm and a good night’s sleep. This is where L-Theanine proves to be highly valuable. A frequently cited study of Lyon MR, Kapoor MP and Juneja LR found that young boys with Attention Deficit Hyperactivity Disorder (ADHD) who took L-Theanine had better sleep than the group of boys who did not.

There are many studies that explore L-Theanine’s benefits apart from stress and anxiety relief. Researchers are finding promising results of L-Theanine’s effectiveness in reducing weight, preventing stroke and helping in cancer treatments.

No conclusive evidence has shown L-Theanine’s negative side effects but it is recommended that pregnant and breastfeeding mothers refrain from its use. For tablets, there are also recommended doses depending on age, weight and other health conditions. It is always best to consult a doctor when planning to take a new supplement. Otherwise, it is believed to be safe.

What Can GABA Amino Acid Do For Me?

GABA amino acid supplements can help you with a number of things. This is a chemical that exists in all of us and plays an important role in how we live our lives.  Here is a little information on it so you can see whether or not it’s a good idea to use it as a supplement.

GABA is something that’s created in your body naturally and it is required to keep your mood in check.  It helps control the fight or flight response and this means that in a lot of people, it controls how much anxiety they feel. People that don’t have the correct balance of GABA amino acid chemicals in their brains are going to feel a lot of anxiety and may have a lot of manic behavior problems. This is why it’s important to take these kinds of supplements if you have any problems with these issues. If you’ve ever drank alcohol then you know that it lowers your inhibitions. This is because it acts on the part of the brain that is responsible for GABA production. When this balance is thrown off, then you’re more likely to do things that you wouldn’t normally do. When the alcohol wears off and you feel all of those anxious feelings, that is because your GABA balance is off. You can only make things better if you abstain from alcohol and use this kind of supplement for it to be effective. Speak with a doctor if you struggle with addiction. You should now know a little more about GABA amino acid and how it can help you if you need it. Make sure that if you do have any extra questions, you ask them to your doctor just so that you can be safe.

Read more comprehensive reports and scientific studies on GABA in the GABA section of our site.

This document was produced by a third party article provider. The opinions and statements are of that organization’s own and the owner and publisher of the site assume no responsibility for the accuracy of the content. Our articles are for informational, educational and entertainment purposes only. Please do your own due diligence, verify any health claims by doing additional research and consult your doctor before starting any supplementation program or making any lifestyle changes, including changes to your medication and supplementation.

Can Amino Acids Help with Weight Loss and Cure Alcoholism?

Amino Acids, or lack thereof, can be a significiant cause behing weight gain. And, amino acids can help reduce alcohol withdrawal symptoms or even help with addictions. In fact, amino acids can be more powerful than street drugs!

If amino acids sound like a crazy way to help with empowering individuals who seem weak-willed regarding overeating, always reaching for comfort foods, and are suffering from emotional stress and are self-medicating, then think again. Amino acids have no come to the rescue! Amino acids are said, by Julia Ross of The Diet Cure, to help with mental health issues since amino acids are 1,000 times stronger than street drugs, such as heroin.

Brain chemistry is the key to amino acids’ powerful mood-enhancing effects

The brain uses neurotransmitters and receptors that alter brain chemistry. Amino acids can be used as a will-power aid since they affect neurotransmitters directly by producing feel-good chemicals in the brain that alleviate the “emotional basket-case” situations of people who cannot seem to get by without reaching for comfort food. Overeating of drug-like foods such as refined flour and sugar, as well as alcohol or other drugs/medicines can slow the production of the brain’s natural chemicals that produce pleasure.

Thinking that your brain’s receptors are “full,” it slows or stops producing them, creating a need to replenish it via more of the same unhealthy consumables that created the problem in the first place. It’s a vicious circle that causes serious health issues like insulin resistance, associated diabetes, and other health problems. Mood-enhancing drugs can therefore wind up being food, sugar, alcohol, cocaine, heroin, or a number of other drugs. Emotional eating then becomes a physical dependency with enough power to keep its users in a co-dependent state of use.

Amino acids from protein or supplements are the key to willpower

Eating protein, and fatty foods that are higher in protein, are the only things that naturally provide the very thing you need to stop those dependencies in their tracks… amino acids! Amino acids make all of the mood-enhancing brain chemicals you may need to find the willpower to slow or stop the intake of those other items that cause the problem. Proteins generally take longer to digest than other foods, too, giving a feeling of satiety.

Your body has to have amino acids. People deficient in them find that supplements and eating more protein in their diets can help them find the relief they need. As always, please consult your doctor before altering your diet or adding amino acid supplements.

Resources:

http://www.alternativementalhealth.com/articles/dietcure.htm

Ross, Julia; Articles on Health: Mental Health and Protein Nutrition; From Well Being Journal Vol. 11, No. 5; Sept/Oct 2002; p. 2