Category Archives: Relaxation

Diazepam Alternative? – Gamma-Aminobutyric Acid

Gamma amino butyric acid (GABA) is a natural sedative, sometimes referred to as natural valium. It may also serve as an alternative to those who cannot take drugs like Diazepam. In fact, Diazepam works by increasing the effect of gamma-aminobutyric acid, so taking GABA as a supplement can help accomplish a similar effect without the same side effects of Diazepam.

What is Gamma-aminobutyric acid (GABA)?

GABA is a non-essential amino acid, which acts as a neurotransmitter in the brain. It works by soaking up extra adrenaline, plus brings relaxation as well as smoothes out activity in the brain.

Gamma-aminobutyric acid has GABAergic effects and the GABA receptor (GABAR) involvement is why anti-anxiety and anti-seizure drugs work, although scientists still don’t understand all the reasons why, but its connection to the suppressing the functions and nerves is well known.

Gamma-aminobutyric acid can be purchased as GABA supplements in most health food or supplement stores; however, doses may vary for use in medical situations and anyone attempting to use it for more than as a sleep aid should consult their physician first.

What is Diazepam?

The common or generic name for Diazepam is Valium. Diazepam is often used to treat acute alcohol withdrawal symptoms, anxiety, and seizures or muscle spasms.

Diazepam belongs to the drug class of benzodiazephines, which affect the brain and central nervous system, so has a calming effect.

Diazepam works by enhancing the natural GABA (gamma-aminobutyric acid) chemical in the body.

Connection between GABAARs and Diazepam-like drugs

According to a study by Andrea N Beltran Gonzales, Pablo E Pomata, et al., titled Benzodiazepine modulation of homomeric GABAAρ1 receptors: Differential effects of diazepam and 4´-chlorodiazepam the “GABAA receptors (GABAARs) are ligand-gated ion channels that mediate inhibitory neurotransmission in the central nervous system … Many GABAARs receptor subtypes are allosterically modulated by benzodiazepines (BDZs), which are drugs extensively used as anxiolytics, sedative-hypnotics and anticonvulsants.”

In their research they said that “human homomeric GABAAρ1 receptors were expressed in Xenopus oocytes and GABA-evoked responses electrophysiologically recorded in the presence or absence of BDZs. … Diazepam produced potentiating effects on GABA-evoked … currents and … diazepam induced biphasic effects depending on the GABA concentration.”

They concluded, “Our results suggest that GABAAρ1 receptor function can be selectively and differentially modulated by BDZs.”

GABA receptors and drugs like Diazepam work by enhancing the gamma-aminobutyric acid effects in the human brain.

Reference:

http://www.sciencedirect.com/science/article/pii/S001429991400661X

http://www.webmd.com/drugs/2/drug-6306/diazepam-oral/details

GABA Stops or Prevents Seizures

GABA, also referred to a gamma-aminobutyric acid, is an amino acid. Amino acids are the building blocks of proteins and serve different functions in the body. Historically this amino has been used as a natural sedative, to help with relaxation and sleep since it is acts as a neurotransmitter in the brain. However, it also has anti-anxiety and anti-seizure properties, and is an anti-convulsant.

GABA is a non-essential amino acid, meaning that the body produces it (you can also get it from protein foods or take a supplement) but sometimes it is still deficient depending on what is happening in the body.

According to studies, this amino acid can aid with sleep, inhibition, calming the nerves, drug dependency (including alcoholism), is used in antiepileptic drugs (epilepsy), and according to a study entitled ‘Molecular mechanisms of antiseizure drug activity at GABAA receptors’ by L John Greenfield Jr, is used to prevent seizures.

GABAA receptor (GABAR) helps prevent seizures

GABAA receptor (GABAAR) is, says the researcher, a “major target of antiseizure drugs (ASD’s).” There are actually a number of different agents that act at GABARs’ distinct receptor sites that can eliminate or prevent seizures.

Some of these agents include: loreclezole, benzodiazepines, and barbiturates, in which the GABARs are the only known substance used due to its antiseizure ability.

However, this is only one of a few possible antiseizure mechanisms in these agents: topiramate, losigamone, retigabine, felbamate, and stiripentol.

Other agents, which affect GABAergic “’tone’ by regulating the synthesis, transport or breakdown of GABA” also exist. The development of ganaxolone was a response to the neurosteroid allopregnanolone (a progesterone metabolite, which intensifies GABAR function).

This amino is an intrinsic component to epileptic patients. The efficacy of GABAR function can change when someone develops or has chronic epilepsy, so Greenfield says that it “may provide an additional target for ‘GABAergic; ASDs.”

The conclusion was that targeting the altered receptors may “provide a novel approach for seizure prevention.”

Reference:

http://www.sciencedirect.com/science/article/pii/S1059131113001143

Buy GABA Online at:

http://www.powdercity.com/products/gaba-powder

 

Improve Sleep for Insomnia via Amino Acids and Deep Breathing

1… 2… 3… 4… How many of us have tried counting sheep, or other things that never seem to work, just to get some sleep at night? Insomnia can strike a person for a good many reasons, including: worry or fretting, stress or anxiety, racing thoughts, sleep cycles being off kilter (light therapy can sometimes help), hormones or metabolic reasons, and even due to being overly tired, among other things. However, there are two natural things you can do to help you sleep… take certain amino acids, and perform certain breathing exercises.

Studies have shown that increasing oxygen levels through deep breathing exercises, contrary to popular belief, can actually help induce sleep rather than wake you up. This is due to the connection with CO2 (carbon dioxide) levels in the body, which I will go into later.

Interestingly, amino acids can also help relieve insomnia. Two of the common 22 amino acids, in particular, are able help calm the mind and induce rest in a weary but aggravated body.

Insomniacs need oxygen, and amino acids for serotonin

Adults with insomnia were studied and given relaxation techniques, including deep breathing exercises (do not forget about bedtime yoga!) as part of information included in complementary and alternative medicine or naturopathic medicine techniques. These insomniacs, after being informed of these easy activities at bedtime, had higher rates of continued use.

Deep breathing exercises aside, it is not just increasing oxygen levels alone that help you relax and slumber, but reducing CO2 levels in the body. Amino acids actually play a vital role in this process.

In a fascinating cross-species study that compared plants, insects, animals, and humans, the levels of CO2 and anxiety were investigated. Anyone who has woken up in the night due to a panic attack knows what I am speaking about here. CO2 levels are higher in correspondence with anxiety or negative emotions.

There is a neurological ‘fear circuit’ that is not entirely understood, but evidence reviewed on the amino acid GABA (gamma-amino butyric acid) may help modulate anxiety that is CO2 induced. That is, if you take the GABA amino acid, it could help calm the mind, anxiety, and troubling thoughts so you can sleep.

Another amino acid that is known to be a natural sedative is tryptophan (like what makes you tired from turkey meat), plus serotonin (the feel-good neurotransmitter) and melatonin also help you induce sleep.

GABA and tryptophan are commonly available as supplements at health food stores and drug stores as a sleep aid. So breathe deeply and reduce the amount of CO2 in your body, plus take amino acid GABA and/or tryptophan to complement this for a good night’s rest.

References:

http://www.ncbi.nlm.nih.gov/pubmed/23243402

http://www.ncbi.nlm.nih.gov/pubmed/18485466

http://www.ncbi.nlm.nih.gov/pubmed/22652369

http://www.ncbi.nlm.nih.gov/pubmed/22365651