In Part 1: Aspartic Acid and Phenylalanine in Aspartame, I covered what the amino acids “aspartic acid” and “phenylalanine” are, and the wood alcohol “methanol” is. Next will be whether any of these have a scientifically known link to cancer or not.

Dangers of aspartame and cancer?

According to some sources claiming aspartame causes cancer, as well as a host of other diseases and health problems, it is important to note that aspartame is made up of approximately 40% aspartic acid, 50% phenylalanine, and 10% methanol. Where some of these sources claim that aspartic acid and phenylalanine could be to blame for health issues, others think that methanol may actually be the culprit.

According to the experts at the American Cancer Society, there is no scientifically discovered proof that aspartame has been linked with cancer. A large study, says the ACS, discussed cancer rates in over 500,000 older adults and found that “compared to people who did not drink aspartame-containing beverages, those who did drink them did not have an increased risk of lymphomas, leukemias, or brain tumors.”

Putting aspartame’s ingredients into perspective

Bernadene Magnuson, PhD, from Cantox Health Sciences International, wrote Relationship Between Aspartame, Methanol and Formaldehyde Explained and put the reality of aspartame into perspective as thus:

“Aspartame is a dipeptide molecule produced by joining phenylalanine and aspartic acid. Aspartame itself does not occur naturally but is a manufactured substance. When aspartame is consumed, it is completely broken down by the enzymes in the digestive system (esterases and peptidases) into the two amino acids and a type of alcohol called methanol. The amounts of these are much less than found in foods. …

“It is important to understand that the human body is well-equipped to use small amounts of methanol produced from foods and beverages, as well as from aspartame. …

“First, the methanol from the intestinal tract goes to the liver via portal blood, where the liver enzyme alcohol dehydrogenase converts methanol into formaldehyde. The body very rapidly uses formaldehyde and so formaldehyde never builds up in the body. If the body doesn’t need it, formaldehyde is converted to formic acid within seconds. The formic acid will be either excreted in the urine or broken down to carbon dioxide and water. …

“The breakdown of formic acid is slower than the breakdown of formaldehyde, so if there is a very large dose of methanol (or formaldehyde) coming into the body, formic acid can build up and that causes the adverse effects seen in methanol poisoning.

“To put this into perspective, studies in healthy adults and infants consuming up to 200mg per kg of body weight (50 times the amounts Americans consume on average), showed no change in the levels of formic acid in the blood.”

Bottom line about aspartic acid, phenylalanine, and methanol

Although the jury is still out for some people on whether aspartame is dangerous, it is clear that aspartic acid and phenylalanine are typically safe for human consumption and needed by the human body.

However, whether small amounts of methanol are “safe” is a factor that some prefer to avoid in their diet, just in case, while others simply consume the poison in these minute amounts. Methanol is typically only poisonous in large quantities. It is really up to the consumer to do the research and decide, as well as seek out professional opinions on the matter.

Please ask your doctor as well, if you have further questions on whether aspartame (or its ingredients aspartic acid, phenylalanine, and methanol) might be safe enough to consume for you in your particular diet and circumstance.

http://www.nlm.nih.gov/medlineplus/ency/article/002234.htm

http://articles.mercola.com/sites/articles/archive/2011/11/06/aspartame-most-dangerous-substance-added-to-food.aspx

http://www.cancer.org/cancer/cancercauses/othercarcinogens/athome/aspartame

http://andevidencelibrary.com/topic.cfm?cat=4089&auth=1